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Zhaolin Xia|CBMN is a more sensitive than WBC count among benzene-exposed workers

Date:2017-07-22Author:
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夏昭林W.jpg


  

Zhaolin Xia

Ph.D

Professor

Deputy Director of Department of Occupational Health and Toxicology

School of Public Health

Fudan University


He is the vice chairman of Occupational Health Specialized Committee in China Occupational Safety and Health Association, the council member of Chinese Society of Toxicology and the standing committee member of Industrial Toxicology Specialized Committee, the standing committee member of Injury Prevention and Control Branch in Chinese Preventive Medicine Association, and the member of Collegium Ramazzini (Italy).

He has mainly engaged in the prevention and control technology of occupational health hazards, including the exposure assessment on the workers exposed to carcinogens, such as benzene, vinyl chloride, etc., exploring the early markers of its genetic damage, developing the detection technology of biomarkers, and carrying out the preliminary prevention, early intervention and detection, as well as the health monitoring, etc. He has published more than 300 papers, of which nearly 60 in English, and won three 2nd class prizes and two 3rd class prizes of the provincial and ministerial science and technology achievement awards.


Topic: CBMN is a more sensitive than WBC count among benzene-exposed workers


Abstract: To assess chromosomal damage, investigate its risk factors, and explore its association with WBC decrease among benzene-exposed workers. Methods: A total of 312 subjects including 219 benzene-exposed workers and 93 unexposed controls were recruited, and the exposed subjects were classified according to WBC count as low, unstable or normal WBC group. Chromosomal damage in peripheral blood samples were evaluated using CBMN assay. Statistical analysis was performed using χ2 test and Poisson regression model. Results: At all of the 23 monitoring sites, benzene air concentration was less than 0.17 ppm (0.6 mg/m3) for three times per day, which is below the national occupational health standard of 1.8 ppm according to the local CDC. The micronucleus (MN) frequencies in the low WBC group (2.75±1.95)‰, unstable WBC group (2.49±1.85)‰ and normal WBC group (2.02±1.63)‰ were all higher values than the control group (1.22±1.12)‰ based on simple Poisson regression (P<0.01). Low and unstable WBC group has a higher average MN frequency than normal WBC group, too. Moreover, with the decrease of WBC count, there is a linear trend of increased micronucleus (MN) abnormality rate among all exposed groups. Compared with unexposed control group, each exposed group has a significantly higher average MN frequency. Low or unstable WBC group has a higher average MN frequency than normal WBC group. Conclusion: Chromosomal damage induced by low-level benzene exposure is correlated with WBC decrease and CBMN might be an early predictor of hematotoxicity/genotoxity among the exposed population.