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Yongqi Zhao|Hypoxia Operating Environment & Semen Quality of Childbearing Age

Date:2017-08-04Author:

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赵永岐W.jpg


  

Yongqi Zhao

Associate Professor

Deputy Director of Department of Military Cognition, Institute of Basic Medicine

Academy of Military Medical Sciences


He graduated from Nankai University in 1995, and received his doctoral degree from Academy of Military Medical Sciences in 2003. He has mainly engaged in the research on cognitive impairment by extreme military environment and ergonomic intervention measures. He has presided over the completion of 2 projects of National Natural Science Foundation of China, three projects of National Science and Technology Major Project "Major new drugs innovation and development", and 2 pre-research projects from General Armament Department of PLA. He also achieved 3 clinical approvals of the national new drug, 1 national medical instrument certificate, 9 authorized invention patents, and won 1st class prize, 2nd class prize and 3rd class prize of Military Science And Technology Progress Awards each.


Topic of Lecture: Hypoxia Operating Environment & Semen Quality of Childbearing Age


Abstract:It is significantly harmful for human health to long-term exposure to high altitude hypoxia environment. However, it is still lack of research for the influence of germ cell development and male reproductive endocrine system on the high altitude hypoxia. Semen analysis is to determine the most basic and important examination methods of male reproductive function and to evaluate important experimental basis in diagnosis of disease. Traditional semen analysis cannot identify the sperm DNA decondensation. However, sperm function tests can identify either sperm malfunction with normal count of semen or sperm abnormalities fertilized by assisted reproductive technology. This method contributes to both improved infertility treatment and facilitates the assessment of environmental effects on spermatogenesis. The aim of this study is to develop detection techniques of semen quality like testing germ cell apoptosis and investigate the related effects on sperm damage mechanism on high altitude hypoxia. Bsaed on the POCT kits of rapid sperm concentration self detection and technology platform of semen quality detection, this work attempted to investigate the sperm damage and its’ mechanism of high altitude hypoxia. Results showed that sperm concentration and activity were significantly lower than some plain areas. Plateau hypoxia can significantly increase the percentage of abnormal sperm, sperm apoptosis, but apoptosis of germ cells had no effect; and abnormal semen viscosity, liquefaction time delay. Electron microscopy showed that the head and nuclear of sperm were hollow, mitochondrial swelling, local axoneme disappeared, the occurrence of apoptosis in the plateau populations. Plateau hypoxia may impact content of Neuropeptide Y and reproductive hormone in human serum in following details: increase of serum testosterone levels; decrease of levels of estrogen, luteinizing hormone, gonadotropin, follicle stimulating hormone; elevation of human chorionic gonadotropin levels, as well as decrease of neuropeptide Y of seminal plasma in plateau population. These results imply that plateau hypoxia can affect related hormones of the neuroendocrine and reproductive system.

This research attempts to investigate many aspects of the damage of sperm on altitude hypoxia for future interventions to provide experimental basis.